Goat antibody to c-terminal of Alpha Synuclein (non-A beta component of AD amyloid): whole serum

Code	OSA00098W
ID Tag	Gt166-280609-WS

Unit size	150 µl
Immunogen	A synthetic peptide from the c-terminal of human Alpha Synuclein (non-A beta component of AD amyloid) conjugated to an immunogenic carrier protein was used as the antigen.
Conjugate	Unconjugated antibody
Accession	ALPHA SYNUCLEIN_HUMAN ALPHA SYNUCLEIN_RAT ALPHA SYNUCLEIN_MOUSE
Also known as	Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, SNCA, NACP, PARK1
Background	Function: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Subcellular location: Cytoplasm. Membrane. Nucleus. Note: Membrane-bound in dopaminergic neurons. Also found in the nucleus. Tissue specificity: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Host	Goat
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity	Specific for Alpha Synuclein.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Okochi M, et al. J. Biol. Chem. 275:390-397(2000) 2. Pronin A.N, et al. J. Biol. Chem. 275:26515-26522(2000) 3. Goers J, et al. Biochemistry 42:8465-8471(2003) 4. Takahashi T, et al. J. Biol. Chem. 278:42225-42233(2003) 5. Choi W, et al. FEBS Lett. 576:363-368(2004)
Limitation	For research use only